diff --git a/docs.it4i/software/bio/omics-master/diagnostic-component-team.md b/docs.it4i/software/bio/omics-master/diagnostic-component-team.md index 375a54fbd19db38a0bfccb453c9d0be698bf4873..2030192763e777e9ae91c375861baad5818a4400 100644 --- a/docs.it4i/software/bio/omics-master/diagnostic-component-team.md +++ b/docs.it4i/software/bio/omics-master/diagnostic-component-team.md @@ -9,7 +9,7 @@ TEAM is available at the [following address][a] ## Diagnostic Component -VCF files are scanned by this diagnostic tool for known diagnostic disease-associated variants. When no diagnostic mutation is found, the file can be sent to the disease-causing gene discovery tool to see whether new disease associated variants can be found. +VCF files are scanned by this diagnostic tool for known diagnostic disease-associated variants. When no diagnostic mutation is found, the file can be sent to the disease-causing gene discovery tool to see whether new disease-associated variants can be found. TEAM (27) is an intuitive and easy-to-use web tool that fills the gap between the predicted mutations and the final diagnostic in targeted enrichment sequencing analysis. The tool searches for known diagnostic mutations, corresponding to a disease panel, among the predicted patient’s variants. Diagnostic variants for the disease are taken from four databases of disease-related variants (HGMD, HUMSAVAR , ClinVar and COSMIC) If no primary diagnostic variant is found, then a list of secondary findings that can help to establish a diagnostic is produced. TEAM also provides with an interface for the definition of and customization of panels, by means of which, genes and mutations can be added or discarded to adjust panel definitions.